A LITTLE LIGHTBULB MOMENT
Pharmacology
The journey of a drug
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A Dramatic Molecule Exits.
The idea behind the cue
Pharmacokinetics organizes drug disposition into absorption, distribution, metabolism and excretion. These concepts describe how a drug enters circulation, moves through the body, is chemically changed and is eliminated.
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Short & simple
A Dramatic Molecule Exits.
Acronym
ADME: A Dramatic Molecule Exits → Absorption, Distribution, Metabolism, Excretion.
Story
A traveler arrives, spreads out across the city, changes along the way, and exits. Follow the drug through absorption, distribution, metabolism and excretion.
Connect the pieces
- A → absorption
- D → distribution
- M → metabolism
- E → excretion
Know the limits
ADME is an organizing framework, not four rigid, nonoverlapping steps. It cannot determine a dose or duration on its own.
Open RN · Pharmacokinetics (CC BY 4.0) ↗Check your understanding
Which processes are components of the pharmacokinetic ADME framework? Select all that apply.
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
E. Receptor agonism
Reveal explanation
Absorption; Distribution; Metabolism; Excretion
ADME describes absorption, distribution, metabolism, and excretion. Receptor agonism describes drug action rather than a disposition component.
Open RN · Pharmacokinetics (CC BY 4.0) ↗